Effect of Different Drugs Influencing Monoamine Neurotransmission on Haloperidol-Induced Catalepsy in Mice

Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and by the serotonin receptor antagonist and reuptake inhibitor nefazodone (maximal increases of 112.4%, 38.5%, 30.8% and 112.4%, respectively). In contrast, the duration of catalepsy was decreased by the serotonin and dopamine reuptake inhibitor sertraline (56.8%, 52.6%, 35.7%); by sibutramine, a serotonin, dopamine and noradrenaline reuptake inhibitor (56.8%, 52.6%, 35.7%); and by Hypericum perforatum (31.9%, 33.2%, 39.6%) at 5, 10, 20 mg/kg, respectively.